Below is a selected list of publications. For the complete list, please check Google Scholar or ORCID.

Selected Publications

  • N. Mathavan, A. Singh, F. C. Marques, et al. Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics. Sci Adv. 2025;11:eadp8496. doi:10.1126/sciadv.adp8496

  • D. Yilmaz, F. C. Marques (equal contribution), et al. Elucidating the mechano-molecular dynamics of TRAP activity using CRISPR/Cas9 mediated fluorescent reporter mice. Heliyon. 2024;10(12):e32949. doi:10.1016/j.heliyon.2024.e32949

  • F. C. Marques, E. Wehrle, R. Müller. Correlative Multimodal Imaging for Multiscale Analysis of Complex Biological Systems: Validation Methods and Performance Analysis. In: Bioimaging in Tissue Engineering and Regeneration. Springer; 2023. doi:10.1007/978-3-030-85569-7_17-1

  • F. C. Marques, D. Boaretti, M. Walle, A. C. Scheuren, F. A. Schulte, R. Müller. Mechanostat parameters estimated from time-lapsed in vivo micro-CT data of mechanically driven bone adaptation are logarithmically dependent on loading frequency. Front Bioeng Biotechnol. 2023;11:1140673. doi:10.3389/fbioe.2023.1140673

  • D. Boaretti, F. C. Marques, et al. Trabecular bone remodeling in the aging mouse: A micro-multiphysics agent-based in silico model using single-cell mechanomics. Front Bioeng Biotechnol. 2023;11:1091294. doi:10.3389/fbioe.2023.1091294

Preprints

  • F. C. Marques, et al. Spatial μProBe: a correlative multimodal imaging approach for spatial profiling of biological micro-environments. bioRxiv. 2025. doi:10.1101/2025.04.23.650252

  • F. A. Schulte, F. C. Marques, et al. Combined physical and pharmaceutical anabolic osteoporosis therapies synergistically increase bone response and local mechanoregulation. bioRxiv. 2024. doi:10.1101/2024.05.16.594551

Conference Abstracts

Oral Podium Presentations

2025

  1. F. C. Marques, A. Singh, N. Mathavan, D. Günther, E. Wehrle, R. Müller. Time-lapsed gene mechanoregulation analysis during bone fracture healing. Abstracts 30th Congress of the European Society of Biomechanics, Zurich, Switzerland, July 6–9, 2025.

  2. F. C. Marques, A. Singh, N. Mathavan, D. Günther, E. Wehrle, R. Müller. Spatial μProBe: a multimodal imaging approach for spatially-resolved gene mechanoregulation analysis during bone fracture healing. Abstracts 33rd Annual Meeting of the European Orthopaedic Research Society (EORS), Davos, Switzerland, June 16–19, 2025.

  3. N. Mathavan, G. Paul, S. Lindenmann, S. Wissmann, F. C. Marques, D. Yilmaz, G. A. Kuhn, E. Wehrle*, R. Müller*. Aging and the mechano-sensitivity of bone healing: Developing an experimental approach to investigate age-dependent mechanobiological responses in bone. Abstracts of the ORS Musculoskeletal Biology Workshop 2025, Utah, USA, July 19–24, 2025.

2024

  1. D. Boaretti, F. C. Marques, G. A. Kuhn, A. Singh, F. A. Schulte, R. Müller. In silico investigation of aging effects on bone mechanobiology: insights from in vivo and computational analysis in aging mice. Abstracts 24th International Workshop on Quantitative Musculoskeletal Imaging (QMSKI), Barossa Valley, Australia, November 3–8, 2024.

  2. F. C. Marques, A. Singh, N. Mathavan, D. Yilmaz, D. Günther, G. A. Kuhn, E. Wehrle, R. Müller. Multiscale Mechanoregulation Analysis Using Super-Resolution Spatial Transcriptomics Data and Multimodal Imaging. XVIth Congress of the International Society of Bone Morphometry (ISBM 2024), Toronto, Canada, September 30–October 3, 2024.

  3. D. Yilmaz, N. Mathavan, F. C. Marques, C. Ledoux, D. Boaretti, D. Whittier, E. Wehrle, G. N. Schädli, A. Singh, G. A. Kuhn, R. Müller. Spatially Resolved Age- and Sex-Specific Alterations in Bone Mechanomics and Mechanoregulation in Prematurely Aged PolgA Mice. Abstracts XVIth Congress of the International Society of Bone Morphometry (ISBM 2024), Toronto, Canada, September 30–October 3, 2024.

  4. F. C. Marques, A. Singh, N. Mathavan, D. Günther, E. Wehrle, R. Müller. Spatial μProbe: Unveiling multiscale mechanoregulation in bone fracture healing through correlative imaging. Abstracts 29th Congress of the European Society of Biomechanics, Edinburgh, UK, June 30–July 3, 2024.

  5. D. Yilmaz, F. C. Marques, D. Boaretti, G. N. Schädli, D. Whittier, N. Mathavan, A. Singh, E. Wehrle, G. A. Kuhn, R. Müller. Unveiling age- and sex-specific impairments in mechanical adaptation of prematurely aged PolgA mice. Abstracts 51st Annual European Calcified Tissue Society Congress (ECTS 2024), Marseille, France, May 25–28, Bone Rep., 2024.

  6. N. Mathavan, A. Singh, F. C. Marques, D. Günther, G. A. Kuhn, E. Wehrle*, R. Müller*. Spatial Transcriptomics in Mechanomics: New Horizons in Exploring the Mechano-regulation of Bone Regeneration. Abstracts Orthopaedic Research Society 2024 Annual Meeting (ORS 2024), Long Beach, California, February 2–6, 2024.

2023

  1. D. Yilmaz, T. Parajasingam, L. Gregorio, C. Gehre, F. C. Marques, N. Mathavan, X.-H. Qin, E. Wehrle, G. A. Kuhn, R. Müller. Prematurely aging PolgA mice exhibit sex-specific hallmarks of musculoskeletal aging. Abstracts ASBMR 2023 Annual Meeting, Vancouver, Canada, October 13–16, J. Bone Miner. Res., 38(2):1039, 2023.

  2. F. C. Marques, A. Singh, N. Mathavan, D. Günther, E. Wehrle, R. Müller. A correlative multimodal imaging approach for spatial transcriptomics mechanoregulation analysis. Abstracts 28th Congress of the European Society of Biomechanics, Maastricht, The Netherlands, July 9–12, 742, 2023.

  3. D. Yilmaz, T. Parajasingam, L. Gregorio, C. Gehre, F. C. Marques, X.-H. Qin, E. Wehrle, G. A. Kuhn, R. Müller. Prematurely aged PolgA mice exhibit degenerated osteocyte network and mechanosensation. Abstracts 28th Congress of the European Society of Biomechanics, Maastricht, The Netherlands, July 9–12, 772, 2023.

  4. F. A. Schulte, J. K. Griesbach, F. C. Marques, C. Weigt, M. von Salis-Soglio, P. J. Richards, M. Kneissel, G. A. Kuhn, R. Müller. Mechanoregulatory changes in trabecular bone when combining bisphosphonate, parathyroid hormone, or sclerostin antibody treatment with mechanical loading in vivo. Abstracts 50th Annual European Calcified Tissue Society Congress (ECTS 2023), Liverpool, UK, May 15–18, COP35, 2023.

2022

  1. F. C. Marques, B. Schroeder, D. Yilmaz, E. Wehrle, R. Müller. A correlative multimodal imaging approach for multiscale analysis of bone regeneration and adaptation. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26–29, 2112, 2022.

  2. D. Yilmaz, F. C. Marques, E. Wehrle, G. A. Kuhn, R. Müller. Mechanoregulation of CRISPR/Cas9 mediated bone cell reporter mice under cyclic mechanical loading. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26–29, 2085, 2022.

  3. J. J. Kendall, D. Boaretti, C. Ledoux, F. C. Marques, E. Wehrle, R. Müller. Emergence of bone remodelling behaviour from a multiphysics agent-based model. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26–29, 2128, 2022.

  4. D. Boaretti, F. C. Marques, J. J. Kendall, G. A. Kuhn, E. Wehrle, Y. D. Bansod, R. Müller. Micro-FE derived mechanical properties for trabecular bone remodeling and adaptation under loading. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26–29, 2027, 2022.

  5. F. C. Marques, P. Schmid, E. Wehrle, R. Müller. Performance comparison of Deep Learning segmentation models on histological sections in a murine bone adaptation and regeneration model. Abstracts IX International Congress on Computational Bioengineering (ICCB 2022), Lisbon, Portugal, April 11–13, 38, 2022.

2021

  1. N. Mathavan, G. R. Paul, F. C. Marques, D. Yilmaz, G. A. Kuhn, E. Wehrle, R. Müller. Individualized cyclic mechanical loading significantly augments the regenerative response of bone in a mouse model of premature aging. Abstracts ASBMR 2021 Annual Meeting, San Diego, USA, October 1–4, J. Bone Miner. Res., 37(S1):339-340, 2021.

  2. F. C. Marques, A. C. Scheuren, E. Wehrle, R. Müller. Mechanostat estimation from time-lapsed in vivo micro-CT mouse data. Abstracts 26th Congress of the European Society of Biomechanics (ESB), Online, Milan, Italy, July 11–14, 1469, 2021.

  3. D. Boaretti, F. C. Marques, E. Wehrle, R. Müller. Towards validation of an in silico model of trabecular bone remodelling in caudal murine vertebra. Abstracts 26th Congress of the European Society of Biomechanics (ESB), Online, Milan, Italy, July 11–14, 1339, 2021.

  4. M. Walle, F. C. Marques, N. Ohs, M. Blauth, R. Müller, C. J. Collins. Bone mechanoregulation allows subject-specific in vivo estimation of microstructural tissue loading history. Abstracts 26th Congress of the European Society of Biomechanics (ESB), Online, Milan, Italy, July 11–14, 1394, 2021.

  5. M. Walle, F. C. Marques, N. Ohs, M. Blauth, R. Müller, C. J. Collins. Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice. Abstracts 48th Annual European Calcified Tissue Society Congress (ECTS 2021), Online, May 6–8, Bone Rep., 14:101032, 2021.

Flash-podium/Hybrid Presentations

2024

  1. F. C. Marques*, D. Yilmaz*, J. Schlatter, C. Gehre, X. H. Qin, E. Wehrle, G. A. Kuhn, R. Müller. An automated image pre-processing pipeline to identify lacunar-canalicular networks from FITC-stained confocal microscopy images. Abstracts 51st Annual European Calcified Tissue Society Congress (ECTS 2024), Marseille, France, May 25–28, Bone Rep., 2024. *equal contribution

2023

  1. F. C. Marques*, D. Yilmaz*, G. R. Çakmak, E. Wehrle, G. A. Kuhn, R. Müller. Osteocytes identified with 2D high-resolution confocal images can be positioned in their 3D local mechanical environment and associated with tissue-level remodelling events. Abstracts 50th Annual European Calcified Tissue Society Congress (ECTS 2023), Liverpool, UK, May 15–18, P236, 2023. *equal contribution

2020

  1. M. Walle, F. C. Marques, N. Ohs, R. Müller, C. J. Collins. 3D physiological load estimation based on time-lapsed HR-pQCT images. Abstracts ASBMR 2020 Annual Meeting, Online, J. Bone Miner. Res., 35(1):143-144, 2020.

Poster Presentations

2025

  1. F. C. Marques, A. Singh, N. Mathavan, D. Günther, E. Wehrle, R. Müller. Inferring cell-type mechanoregulation during fracture healing using spatial transcriptomics. Abstracts 30th Congress of the European Society of Biomechanics, Zurich, Switzerland, July 6–9, 2025.

  2. N. Mathavan, G. Paul, S. Lindenmann, S. Wissmann, F. C. Marques, D. Yilmaz, G. A. Kuhn, E. Wehrle*, R. Müller*. Investigating the effect of aging on the mechano-sensitivity of bone regeneration across both sexes in a mouse model of premature aging. Abstracts 52nd Annual European Calcified Tissue Society Congress (ECTS 2025), Innsbruck, Austria, May 23–26, Bone Rep., 2025.

2024

  1. F. C. Marques, A. Singh, N. Mathavan, D. Yilmaz, D. Günther, G. A. Kuhn, E. Wehrle, R. Müller. Multiscale Mechanoregulation Analysis Using Super-Resolution Spatial Transcriptomics Data and Multimodal Imaging. Abstracts ASBMR 2024 Annual Meeting, Toronto, Canada, September 27–30, 2024.

  2. D. Yilmaz, N. Mathavan, F. C. Marques, C. Ledoux, D. Boaretti, D. Whittier, E. Wehrle, G. N. Schädli, A. Singh, G. A. Kuhn, R. Müller. Spatially Resolved Age- and Sex-Specific Alterations in Bone Mechanomics and Mechanoregulation in Prematurely Aged PolgA Mice. Abstracts ASBMR 2024 Annual Meeting, Toronto, Canada, September 27–30, 2024.

  3. N. Mathavan, G. Paul, S. Lindenmann, S. Wissmann, F. C. Marques, D. Yilmaz, G. A. Kuhn, E. Wehrle, R. Müller. Sexual Dimorphism in the Mechanosensitivity of Bone Regeneration with Aging. Abstracts ASBMR 2024 Annual Meeting, Toronto, Canada, September 27–30, 2024.

  4. F. C. Marques, R. Müller. Accuracy of a multimodal 2D-3D registration algorithm in comparison with gold-standard landmarking registration. Abstracts 29th Congress of the European Society of Biomechanics, Edinburgh, UK, June 30–July 3, accepted, 2024.

  5. F. A. Schulte, J. K. Griesbach, F. C. Marques, C. Weigt, M. von Salis-Soglio, F. M. Lambers, P. J. Richards, M. Kneissel, G. A. Kuhn, R. Müller. Comparative analysis of mechanoregulatory trabecular bone adaptations in response to mechanical loading or sclerostin antibody treatment. Abstracts 51st Annual European Calcified Tissue Society Congress (ECTS 2024), Marseille, France, May 25–28, Bone Rep., 2024.

2023

  1. F. C. Marques, E. Wehrle, R. Müller. Validation of a multimodal 2D-3D registration algorithm using unimodal synthetic experiments. Abstracts 28th Congress of the European Society of Biomechanics, Maastricht, The Netherlands, July 9–12, 749, 2023.

  2. D. Yilmaz, J. Schlatter, F. C. Marques, C. Gehre, X. H. Qin, E. Wehrle, G. A. Kuhn, R. Müller. Degenerated 3D osteocyte lacuno-canalicular network in a mouse model of premature aging. Abstracts 50th Annual European Calcified Tissue Society Congress (ECTS 2023), Liverpool, UK, May 15–18, P237, 2023.

  3. E. Wehrle, D. Günther, N. Mathavan, F. C. Marques, A. Singh, R. Müller. Spatial transcriptomics of musculoskeletal tissues during bone healing in mice. Abstracts Orthopaedic Research Society 2023 Annual Meeting (ORS 2023), Dallas, Texas, February 10–14, 2023.

2022

  1. F. A. Schulte, C. Weigt, M. von Salis-Soglio, J. Griesbach, F. C. Marques, M. Kneissel, P. J. Richards, G. A. Kuhn, R. Müller. Mechanical loading increases trabecular bone response additively or synergistically when combined with parathyroid hormone, bisphosphonate or sclerostin antibody treatment. Abstracts ASBMR 2022 Annual Meeting, Austin, USA, September 9–12, J. Bone Miner. Res., 38(1):197, 2022.

  2. E. Wehrle, D. Günther, K. Kataoka, F. C. Marques, N. Mathavan, D. Yilmaz, F. Minacci, L. Gregorio, A. Singh, G. A. Kuhn, R. Müller. Towards spatial in vivo mechanomics of musculoskeletal regeneration. Abstracts XVth Congress of the International Society of Bone Morphometry (ISBM 2022), Odense, Denmark, July 10–13, 2022.

  3. F. C. Marques, D. Yilmaz, E. Wehrle, R. Müller. Large-scale quantification of osteocyte morphometry and protein expression from murine bone histology. Abstracts 27th Congress of the European Society of Biomechanics (ESB), Porto, Portugal, June 26–29, 2413, 2022.

  4. N. Mathavan, L. Gregorio, F. C. Marques, G. A. Kuhn, R. Müller, E. Wehrle. Evaluation of a CRISPR/Cas9-based dual-fluorescent reporter mouse model of premature aging to investigate the mechanobiology of bone regeneration. Abstracts 49th Annual European Calcified Tissue Society Congress (ECTS 2022), Helsinki, Finland, May 6–10, Bone Rep., 16:101349, 2022.

  5. J. J. Kendall, D. C. Tourolle, D. Boaretti, F. C. Marques, E. F. Morgan, R. Müller. Micro-Multiphysics Agent-Based Modeling of Revascularization during Bone Healing. Abstracts Orthopaedic Research Society 2022 Annual Meeting (ORS 2022), Tampa, Florida, February 4–8, 2022.

2021

  1. D. Yilmaz, F. C. Marques, E. M. Wehrle, G. A. Kuhn, R. Müller. CRISPR/Cas9 mediated dual fluorescent reporter mice response to in vivo mechanical loading. Abstracts ASBMR 2021 Annual Meeting, San Diego, USA, October 1–4, J. Bone Miner. Res., 37(S1):206-206, 2021.

  2. F. C. Marques, A. C. Scheuren, E. Wehrle, R. Müller. Quantification of mechanoregulation from time-lapsed in vivo micro-CT mouse data. Abstracts 26th Congress of the European Society of Biomechanics (ESB), Online, Milan, Italy, July 11–14, 1472, 2021.